Product name | Alarelin |
Product No. | 600655 |
Sequence | Glp-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt |
Appearance | White or off-white powder |
Solubility | Sparingly soluble in MeOH, soluble in water and 1% acetate acid |
Specific optical rotation | (-46°to -56°) (C=0.5%; 1% acetic acid,anhydrous and acetic acid free subtance) |
Water | ≤5.0% |
Amino acid analysis | Arg 0.9-1.1 Pro 0.8-1.0 |
His 0.9-1.1 Tyr 0.9-1.1 | |
Leu 0.9-1.1 Glu 0.9-1.1 | |
Ala 0.9-1.1 Ser 0.7-1.0 | |
Related substances | Any impurity: NMT 1.0% Total impurity: NMT 2.0% |
Assay | 95.0%-103.0%(anhydrous and acetic acid free substance) |
Acetate acid | ≤7.5% |
MS | 1167.34±1.0 |
Storage Condition | In an air tight container, protected from light at temperature 2-8℃. |
Application field: Alarelin acetate is a synthetic GnRH agonist.Alarelin could inhibit the gastric acid secretion both by direct actions on parietal cells in rats and by inhibiting vagous function. Alarelin could significantly enhance ratio of G1 phase and decrease ratio of S phase of GSMC of rats.